Duke heads to a men's Final Four made up of all No. 1 seeds as the favorite to win the national championship. The Blue Devils were +105 to win the title at ESPN BET after the Final Four was set on Sunday.

Top seeds Duke, Florida, Houston and Auburn saw minimal movement atop the title odds during dominant postseason runs. Despite this year’s Elite Eight teams tying with the 2007 tourney for the lowest combined seed total (13) in tournament history, the four No. 1 seeds demolished four quality opponents by an average of 12.5 points.

Duke will be the team to beat in San Antonio, Texas, next week for the 2025 Final Four, according to betting lines that opened at the conclusion of the NCAA Tournament's second weekend on Sunday. The Blue Devils have the shortest odds at +105 to win the national championship ahead of Florida,