Flagg had 28 points, five rebounds, four assists, two steals and two blocked shots to help the No. 3 Blue Devils beat Boston College 88-63 for their 12th win in a row.
The Eagles prepare for the Divisional Round against the Rams, with a potential Super Bowl run and college star Abdul Carter's Philadelphia dreams sparking conversation.
The Eagles scored the first 8 points of the game, led 32-9 lead after the first quarter, and the lead never dropped to less than 21 for the rest of the game.