With Norman Osborn on board, we could potentially see a younger Otto before he became Doc Ock. Marvel has a huge Spider-Man universe to draw from, and season 2 could bring even more familiar faces.

Willem Dafoe made his debut as the villainous Norman Osborn in 2002's Spider-Man, though the Green Goblin's story reached a definitive, comic-accurate end when he was impaled by his glider.