Axonal degeneration and neuroinflammation are critical processes involved in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Recent research has ...

To test this, we utilized mice deficient in Sarm1 (Sarm1-/-), a molecular trigger of axon degeneration and the loss of which leads to axonal protection after injury. Methods: Wildtype and Sarm1-/-male ...

Axonotmesis indicates a loss of axon continuity, though the endoneural tube is preserved. This structural injury results in wallerian degeneration. Severe crush or traction injuries can produce ...

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

All the classic features of ALS are produced: misaccumulated neurofilaments in spinal cord and brainstem motor neurons, degeneration of motor axons and the characteristic denervation-induced ...

Damage to myelin, the protective sheath surrounding nerve fibers, impairs the brain's ability to transmit signals efficiently ...

"Familial dysautonomia specifically affects development and causes degeneration of the peripheral ... genipin boosted the regeneration of severed axons into healthy sensory and cortical neurons.

Augustine Therapeutics appoints Gerhard Koenigas Chief Executive Officer as Company Prepares to Enter the ClinicIndustry veteran Gerhard Koenig, ...

“Based on several preclinical efficacy studies and what is known about the central role of calpain-2 in the process of axonal degeneration, we believe AMX0114 has the potential to be a treatment ...