Today, the cause of sickle cell disease is well understood to be a point mutation in a hemoglobin gene called HBB that makes red blood ... in his basement to study how the molecule’s structure ...

Sickle-cell anemia is due to a mutation in the gene encoding the β-subunit of hemoglobin (called HBB), which leads to an abnormal structure of the β-subunit protein chain and the sickle-cell ...

The atomic structure of hemoglobin, determined by Max Perutz and colleagues 4, showed that this residue position is located on the surface of the protein. The mutation makes sickle cell hemoglobin ...

"We also observed defects in metabolism and mitochondria structure and performance ... They found that this gene therapy approach significantly boosted hemoglobin and red blood cell levels ...

A gene known as HbS was the center of a medical and evolutionary detective story that began in the middle 1940s in Africa. Doctors noticed that patients who had sickle cell anemia, a serious ...

Each gene within that cell has a coding region. This region encodes the information used to make a particular protein, such as the hemoglobin in the red blood cells seen here. (Hemoglobin shuttles ...

If a mutation occurs in a gene that results in a change to the sequence of DNA bases, then the structure of the protein ... of the gene that codes for haemoglobin. The protein that is coded ...